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KMID : 1190620100060010010
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Journal of the Korean Wound Care Society
2010 Volume.6 No. 1 p.10 ~ p.14
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Effect of Hydrogel Dressing for Wound Healing in Full-thickness Wound on Nude Mouse
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Lim Sae-Hwan
Yu Hyeong-Uk
Yoon So-Jeong
Park Chan-Woong
Oh Kap-Sung
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Abstract
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PlusubgelTM (MCTT Co. Ltd) is a new amorphous hydrogel wound dressing that are specially formulated to help provide a moist environment to enhance wound healing. Hydrogel wound dressing help to maintain a moist wound environment recognized as being beneficial in wound healing. They are non-adherent and can be removed without trauma to the wound. In addition, hydrogel wound dressings are effective, comfortable, easy to use and cost effective. This study was designed to evaluate the wound healing effects of PlusubgelTM in the treatment of full-thickness wounds (8 mmØ) in mice. A total of 60 mice were used in this study. 30 mice were treated with PlusubgelTM, followed by second dressing (i.e. Mepitel? & Tegaderm?), and 30 mice with a second dressing alone. Biopsy samples were taken at 4, 7 and 14 days post operation, and each wound site was examined histopathologically. Histopathologic evaluation included monitoring of epithelialization and granulation tissue formation. The results were as follow; Acceleration of epithelization across the wound surface was noted following PlusubgelTM treatment. Increase in the thickness of granulation tissue was observed in the PlusubgelTM-treated groups as compared with the control groups. It can be concluded that PlusubgelTM might be a potential treatment material for wound healing. (J Korean Wound Management Soc 2010;6:10-14)
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KEYWORD
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Hydrogel dressing, Wound healing, Epithelialization
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